Liverpool boss Jurgen Klopp has made eight changes to the side that beat Sunderland to face Leeds United.
Divock Origi, who scored the opener in the 2-0 victory on Saturday, will start up top in place of Roberto Firmino.
There are starts for young duo Trent Alexander-Arnold and Ovie Ejaria as well, while Kevin Stewart is given an opportunity in midfield.
Just three players have kept their place in the side and they are Georginio Wijnaldum, Sadio Mane and Emre Can.
Lucas Leiva will wear the armband as he is partnered in defence by Ragnar Klavan as the pair shield returning goalkeeper Simon Mignolet.
Liverpool: Mignolet, Alexander-Arnold, Klavan, Lucas, Moreno, Stewart, Ejaria, Wijnaldum, Can, Mane, Origi.
Substitutes: Karius, Lovren, Clyne, Henderson, Milner, Woodburn, Grujic.